What is Avastin?
Avastin is a brand-name prescription drug. It is only for people 18 years of age and older with the following conditions:
- Metastatic colorectal cancer.
- Non-small cell lung cancer
- Metastatic kidney cancer
- Some forms of cancer that affect the fallopian tubes, ovaries, or peritoneum (the lining of the abdomen)
- Recurrent glioblastoma (a type of brain cancer)
- Some forms of cervical cancer
Depending on the type of cancer being treated, Avastin is often used in combination with chemotherapy. Chemotherapy describes traditional medicine used to treat cancer. Eustace is not a chemotherapy drug. Avastin contains bevacizumab. It is a monoclonal antibody, a type of drug produced by the cells of the immune system. Bevacizumab belongs to a class of medications called vascular endothelial growth factor (VEGF) inhibitors. (Medicine class is a group of drugs that works the same way).
Generally, you will receive Avastin infusions every 2 to 3 weeks during treatment.
Avastin injection is only available as a brand-name medicine. It is not currently available in generic form. Avastin contains the active drug bevacizumab. Although there is no common form of bevacizumab, a biosimilar form called Mvasi is available. A biosimilar is a brand-name biological drug-like drug, such as Eustace. Natural pills are made up of living cells.
It is not possible to make an exact copy of these medicines. On the other hand, a generic drug is a precise replica of a brand-name drug made from chemicals. Biosmallers are considered safe and effective as their primary medicine.
The Food and Drug Administration (FDA) approves prescription medications to treat certain conditions, such as Eustace. Avastin can also be used off-label for other states. Off-label use occurs when an approved drug is used to treat a different situation.
Avastin for glioblastoma
FDA approve Avastin injection for the treatment of recurrent glioblastoma. This cancer is an aggressive type of brain cancer. With recurrent glioblastoma, cancer responded to the previous treatment but returned after a while. Glioblastomas grow rapidly inside the brain. But they rarely spread to other parts of the body. Glioblastomas belong to a group of tumours called astrocytomas. (The name “astrocytoma” comes from the cells these tumours start, called astrocytes.)
Effectiveness for glioblastoma
In a clinical study of people with recurrent glioblastoma, the researchers examined whether Avastin chemotherapy was more effective than lomustine alone in combination with the drug lomustine. In the study, people who took Avastin with lomustine had better results than those who took lomustine alone. Significantly, half of those who took Avastin with chemotherapy spent at least 4.2 months without developing cancer. By comparison, half of the people who take lomustine alone spend at least 1.5 months without developing cancer.
Avastin for ovarian cancer
The FDA has approved Avastin to treat cancer of the ovaries, fallopian tubes, or peritoneum (the lining of the abdomen). It is important to note that some cancers of the fallopian tubes and peritoneum may be so similar to ovarian cancer that they are sometimes labelled ovarian cancer.
Avastin is used in the following conditions:
Stage 3 and stage 4 cancer, In these stages, cancer has spread from the area where it started to other body parts. For this use, Avastin injection is given when cancer has already been cured by surgery. At the beginning of treatment, Avastin is used with two chemotherapy drugs called carboplatin and paclitaxel. (Chemotherapy describes traditional medicine used to treat cancer.) After a while, Avastin is used on its own.
Recurrent cancer is resistant to certain platinum-based treatments. With recurrent cancer, cancer responded to the previous treatment but returned after a while. With resistance, cancer no longer responds to certain treatments. For this use, Avastin is given to people who have used two chemotherapy drugs in the past. And It is used in combination with some other drugs.
Recurrent cancer that responds to some platinum-based treatments. For this use, We combine it with some chemotherapy drugs. For example, we use carboplatin or gemcitabine or with carboplatin and paclitaxel. After a while, you can use it alone.
In a clinical study, researchers examined whether adding Avastin to chemotherapy was more effective in treating ovarian cancer than those who had already had surgery. Researchers have found that, on average, cancer progresses more slowly in people who take Avastin injection with chemotherapy.
For example, half of the people who took Avastin lived 18.2 months or more before developing cancer. By comparison, half of those who took a placebo lived 12 months or more before cancer developed.